"Immunohistochemical analysis of Sigma-1 receptor (σ-1R) expression in human pineal gland in relation to different causes of death".

Sigma-1 receptor (σ-1R) modulates cellular signaling pathways, probably acting as a ligand operated chaperone. When activated, the receptor translocates from the interface mitochondrion associated membrane of the endoplasmic reticulum to the cell membrane. σ-1R was demonstrated in some brain regions, including the pineal gland, and was proposed to be involved in several cerebral processes, including neuroprotective responses against homeostasis alterations. On this basis, the immunohistochemical expression of σ-1R in human pineal glands was evaluated, with particular regard to the different causes of death. Thirty-eight pineal glands obtained from forensic autopsies were divided into five groups according to the cause of death: sudden death, drowning, fire fatality, hanging, and hemorrhagic shock, and examined with hematoxylin-eosin stain and immunohistochemistry for σ-1R. Both pinealocytes and perivascular spaces were evaluated. The pineal glands from sudden death were only mildly positive for σ-1R, while a more evident immunopositivity was observed in hanging, fire fatality, hemorrhagic shock, and drowning. These results were confirmed in a two-by-two comparison between the sudden death group and other groups. Our data demonstrate for the first time with immunohistochemical techniques the presence of σ-1R expression in the human pineal gland and propose a direct correlation between σ-1R expression and duration of the death process, in particular when hypoxic conditions and/or excessive psychological stress are present.

Union With Recursive Feature Elimination: A Feature Selection Framework to Improve the Classification Performance of Multicategory Causes of Death in Colorectal Cancer.

Despite the use of machine learning tools, it is challenging to properly model cause-specific deaths in colorectal cancer (CRC) patients and choose appropriate treatments. Here, we propose an interesting feature selection framework, namely union with recursive feature elimination (U-RFE), to select the union feature sets that are crucial in CRC progression-specific mortality using The Cancer Genome Atlas (TCGA) dataset. Based on the union feature sets, we compared the performance of 5 classification algorithms, including logistic regression (LR), support vector machines (SVM), random forest (RF), eXtreme gradient boosting (XGBoost), and Stacking, to identify the best model for classifying 4-category deaths. In the first stage of U-RFE, LR, SVM, and RF were used as base estimators to obtain subsets containing the same number of features but not exactly the same specific features. Union analysis of the subsets was then performed to determine the final union feature set, effectively combining the advantages of different algorithms. We found that the U-RFE framework could improve various models' performance. Stacking outperformed LR, SVM, RF, and XGBoost in most scenarios. When the target feature number of the RFE was set to 50 and the union feature set contained 298 deterministic features, the Stacking model achieved F1_weighted, Recall_weighted, Precision_weighted, Accuracy, and Matthews correlation coefficient of 0.851, 0.864, 0.854, 0.864, and 0.717, respectively. The performance of the minority categories was also significantly improved. Therefore, this recursive feature elimination-based approach of feature selection improves performances of classifying CRC deaths using clinical and omics data or those using other data with high feature redundancy and imbalance.

Changing Mortality and Patterns of Death Causes in HIV Infected Patients - China, 2013-2022.

What is already known about this topic?: The advent of antiretroviral therapy (ART) has markedly decreased mortality rates among patients infected with human immunodeficiency virus (HIV). Globally, there has been a 43% reduction in acquired immunodeficiency syndrome (AIDS)-related deaths from 2010 to 2022. Additionally, prior research indicates that the initiation of ART at an early stage within China has substantially lowered mortality rates. What is added by this report?: Over the previous decade, following the implementation of China's universal ART access strategy, the patterns of mortality causes among HIV-infected individuals across the country have undergone significant alterations. In 2022, the all-cause mortality rate among this population was reported at 2.7%, with the non-AIDS-related mortality rate at 1.8%. However, it is important to consider that the accuracy of death reporting could contribute to potential misclassification of the underlying causes of death. What are the implications for public health practice?: Efforts to enhance health outcomes should persist in emphasizing the advancement of ART strategies, with a particular focus on mitigating non-AIDS-related mortality in the future.

Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia.

INTRODUCTION: With scarce comparative data on mortality in Australian patients with rheumatoid arthritis (RA), we investigated temporal changes in standardized mortality rates for patients with RA using longitudinal linked population-wide health data in Western Australia (WA) over the period 1980 to 2015. METHODS: The study included 17,125 patients with a first-time hospital contact for RA (ICD-10-AM M05.00-M06.99 and ICD-9-AM 714.00-714.99) in the study period. Standardized mortality rate ratios (SMRRs) for the RA cohort versus the WA general population was estimated using direct age standardization. We analyzed temporal trends over with dates and causes provided by the WA Death Registry. RESULTS: During 356,069 patient-years of follow-up, a total of 8955 (52%) deaths occurred in the RA cohort. The SMRR was 2.24 (95% CI 2.15-2.34) in males and 3.09 (95% CI 3.00-3.19) in females over the study period. SMRR decreased since 2000 to 1.59 (95% CI 1.39-1.81) for the period 2011-2015. Median survival was 26.80 years (95% CI 26.30-27.30), where age and comorbidity independently increased the risk of death. The leading causes of deaths were cardiovascular diseases (26.60%), cancer (16.80%), rheumatic diseases (5.80%), chronic pulmonary disease 491 (5.50%), dementia (3.00%), and diabetes 235 (2.6%). CONCLUSIONS: The mortality rate in patients with RA in WA has decreased but remains 1.59-times higher than in community counterparts, suggesting that there is room for further improvement. Comorbidity is the main modifiable risk factor to further reduce mortality in patients with RA.

[Epidemiological consideration for death causes among Japanese: focused on age, time, and birth cohort effects].

This study aimed to clarify the death causes among Japanese. National vital statistics data from 1995 to 2020 were analyzed using the mean polish process. The results showed that deaths from cancer increased after middle age, and deaths from heart disease, pneumonia, and cerebrovascular disease increased after later life (age effect). Recently, mortality from cerebrovascular disease, heart disease, and pneumonia is decreasing (time effect). More individuals in the birth cohort born after 1906 died from cancer compared to that of earlier generations who mainly died from heart disease, pneumonia, and cerebrovascular disease (birth cohort effect). The time effect is more modifiable and/or depending on social conditions and interventions compared to that of the age effect. In Japan, if lifestyle-related diseases that are risk factors for cerebrovascular and heart diseases, such as hypertension, are further prevented or treated, mortality from such diseases will decrease consequently.

Trends in mortality and causes of death among Chinese adolescents aged 10-19 years from 1990 to 2019.

Objective: Promoting adolescent health is essential to achieving the goals of the Healthy China 2030 (HC 2030) initiative. As socioeconomic conditions improve and medical practices and disease patterns evolve, adolescent mortality rates and causes of death vary considerably. This study provides up-to-date data on adolescent mortality and causes of death in China, highlighting key areas of focus for investment in adolescent health. Methods: Data regarding mortality and causes of death in Chinese adolescents aged 10-19 years were extracted from the Global Burden of Disease study from 1990 to 2019. The data variables were examined according to year, sex, and age. The autoregressive integrated moving average model was used to predict non-communicable disease (NCD) mortality rates and rank changes in the leading causes of death until 2030. Results: The all-cause mortality rate (per 100,000 population) of Chinese adolescents aged 10-19 years steadily declined from 1990 (72.6/100,000) to 2019 (28.8). Male adolescents had a higher mortality (37.5/100,000 vs. 18.6 in 2019) and a slower decline rate (percent: -58.7 vs. -65.0) than female adolescents. Regarding age, compared with those aged 10-14 years, the mortality rate of adolescents aged 15-19 years had a higher mortality (35.9/100,000 vs. 21.2 in 2019) and a slower decrease rate (percent: -57.6 vs. -63.2). From 1990 to 2019, the rates of communicable, maternal, and nutritional diseases declined the most (percent: -80.0), while injury and NCDs mortality rates were relatively slow (percent: -50.0 and -60.0). In 2019, the five leading causes of death were road injuries (6.1/100,000), drowning (4.5), self-harm (1.9), leukemia (1.9), and congenital birth defects (1.3). Furthermore, NCDs' mortality rate decreased by -46.6% and -45.4% between 2015-2030 and 2016-2030, respectively. Conclusion: A notable decline was observed in all-cause mortality rates among Chinese adolescents aged 10-19 years. In addition, the mortality rates of NCDs are projected to meet the target from the Global Strategy for Women's, Children's, and Adolescents' Health (2016-2030) and HC2030 reduction indicators by 2030. However, it should be noted that injury is the leading cause of death, with sexual and age disparities remaining consistent.

Analysis of death causes of residents in poverty-stricken Areas in 2020: take Liangshan Yi Autonomous Prefecture in China as an example.

BACKGROUND: Continuous surveillance of death can measure health status of the population, reflect social development of a region, thus promote health service development in the region and improve the health level of local residents. Liangshan Yi Autonomous Prefecture was a poverty-stricken region in Sichuan province, China. While at the end of 2020, as the announcement of its last seven former severely impoverished counties had shaken off poverty, Liangshan declared victory against poverty. Since it is well known that the mortality and cause of death structure will undergo some undesirable changes as the economy develops, this study aimed to reveal the distribution of deaths, as well as analyze the latest mortality and death causes distribution characteristics in Liangshan in 2020, so as to provide references for the decision-making on health policies and the distribution of health resources in global poverty-stricken areas. METHODS: Liangshan carried out the investigation on underreporting deaths among population in its 11 counties in 2018, and combined with the partially available data from underreporting deaths investigation data in 2020 and the field experience, we have estimated the underreporting rates of death in 2020 using capture-recapture (CRC) method. The crude mortality rate, age-standardized mortality rate, proportion and rank of the death causes, potential years of life lost (PYLL), average years of life lost (AYLL), potential years of life lost rate (PYLLR), standardized potential years of life lost (SPYLL), premature mortality from non-communicable diseases (premature NCD mortality), life expectancy and cause-eliminated life expectancy were estimated and corrected. RESULTS: In 2020, Liangshan reported a total of 16,850 deaths, with a crude mortality rate of 608.75/100,000 and an age-standardized mortality rate of 633.50/100,000. Male mortality was higher than female mortality, while 0-year-old mortality of men was lower than women's. The former severely impoverished counties' age-standardized mortality and 0-year-old mortality were higher than those of the non-impoverished counties. The main cause of death spectrum was noncommunicable diseases (NCDs), and the premature NCD mortality of four major NCDs were 14.26% for the overall population, 19.16% for men and 9.27% for women. In the overall population, the top five death causes were heart diseases (112.07/100,000), respiratory diseases (105.85/100,000), cerebrovascular diseases (87.03/100,000), malignant tumors (73.92/100,000) and injury (43.89/100,000). Injury (64,216.78 person years), malignant tumors (41,478.33 person years) and heart diseases (29,647.83 person years) had the greatest burden on residents in Liangshan, and at the same time, the burden of most death causes on men were greater than those on women. The life expectancy was 76.25 years for overall population, 72.92 years for men and 80.17 years for women, respectively, all higher than the global level (73.3, 70.8 and 75.9 years). CONCLUSIONS: Taking Liangshan in China as an example, this study analyzed the latest death situation in poverty-stricken areas, and proposed suggestions on the formulation of health policies in other poverty-stricken areas both at home and abroad.

[The alteration of the structure of mortality of endocrine system diseases, nutrition disorders and metabolic disturbances in individuals of able-bodied age and older in conditions of pandemic].

The elderly age and endocrine diseases are among death risk factors at contamination with new coronavirus infection. To reply the question of how the influence of these risk factors is summing up, differences were determined concerning patterns of changes in structure of mortality of endocrine system diseases, nutrition disorders and metabolic disturbances in individuals of able-bodied age and older against the background of COVID-19 pandemic. on the basis of information from the Moscow database of deaths of endocrine system diseases, nutrition disorders and metabolic disturbances, the changes in contribution of individual diseases to the death causes structure in 2019-2021 were analyzed. The groups of individuals of able-bodied age and older were compared. It was established that in both groups rate of indicating SARS-CoV-2 virus infection as concomitant disease decreased while rate of indicating concomitant diseases at death of COVID-19 increased. The group differences in changes of structure of death causes were established in 2021. The percentage of undetermined forms of diabetes and obesity in structure of death causes increased in the elderly, while in individuals of able-bodied age increased. The percentage of obesity as concomitant disease of death of COVID-19 in individuals of able-bodied age increased and did no change were detected in the elderly group. The input of poly-glandular dysfunction as consequence of old infection into mortality is five times higher among individuals of able-bodied age. On the basis of received results, assumption was made SARS-CoV-2 virus contamination ruinously affects development of pathological process under endocrine diseases regardless of age, while age affects spreading of endocrine diseases and degree of resistance to development of infectious process directly. The differences in patterns of changes of structure of death causes of population of able-bodied age and older are associated with low quality of diagnostics of death causes in individuals of elder age groups.

[Dynamics of mortality according to the materials of the forensic medical examination bureau of a particular region]. / Dinamika smertnosti po materialam byuro sudebno-meditsinskoi ekspertizy otdel'no vzyatogo regiona.

OBJECTIVE: To show the dynamics of the structure of deaths of the main types of violent and non-violent death on the material of the thanatological department of a separate regional bureau of forensic medical examination. Among the violent causes are considered: mechanical injury, mechanical asphyxia, transport injury, poisoning. Among the nonviolent causes of death the diseases of circulatory system, pneumonia, infectious and oncological pathology have been studied. The period from 2001 to 2020 was investigated. Dynamic changes over a selected period are most clearly demonstrated by the ratio of numerical data to the original 2001 indicators taken as 100%. The data presented objectively reflecting the dynamics of the number and proportion of certain types of death are only the initial stage of the analysis undertaken. The second step should be the determination of the causes of the identified changes that require an integrated approach including medical, demographic and socio-economic data.

Surveillance and analysis of death causes of residents in a community of Shanghai from 2017 through 2019 / 上海预防医学

Objective:To determine the mortality， composition and trend of death causes of residents in Changxing community， Chongming District， Shanghai from 2017 through 2019， and provide scientific evidence for disease prevention and control strategies. Methods:Mortality data of household registered population in this community during January 1， 2017， and December 31， 2019， were collected. Causes of death were coded according to the ICD-10 and then analyzed by descriptive epidemiological method. Results:From 2017 through 2019， crude annual mortality of household registered residents in Changxing Community was 816.32/105， 825.01/105， and 770.16/105， respectively. The average annual mortality was 803.82/105. The leading death causes were cancer， circulatory disease， respiratory disease， and injury， poisoning and other external causes. Male mortality was higher than female mortality in all years. Conclusion:Main death causes of residents in Changxing Community are chronic non-communicable diseases， followed by external causes of injuries and poisoning. Our study provides scientific evidence for the improvement of health strategies by the local health administration， which warrants targeted health education measures to reduce the morbidity and mortality of chronic diseases and improve the health.

[Quality of accounting of death causes for elderly people].

Programs to increase the life expectancy of old people are becoming increasingly relevant in an aging society. Their adequacy depends on the quality of accounting death causes. Objective: To evaluate the quality of accounting of death causes for population over the working age. For 98 061 deaths of people over working age registered in Moscow dead database, the structure of underline and multiple causes of death were compared. To determine whether information on morbidity of elderly can improve the diagnosis of death causes the structure of death causes was compared with officially registered prevalence and detected prevalence. The last was calculated on the basis of the household survey of health of elderly population in Nizhny Novgorod Region (22 558 people). We find fundamental difference between the structure of causes for officially registered prevalence, detected prevalence and mortality. In the structure of death causes the nervous diseases are in the second place and the proportion of uncertain death causes is 6.7%. The difference in the structure of underline and multiple causes of death is not so great. For people over working age, the coding errors were detected in 9.8% underline death causes. Thus, morbidity statistics cannot provide informational support for diagnosing causes of death in full. To improve the quality of accounting of death causes, it is advisable to introduce the institution of coders and to give them the possibility of verifying death diagnoses in medical organizations where the diagnosis has been established.

Autopsias en fallecidos de la tercera edad / Autopsies in elderly deceased elderly

Introducción: La Organización Mundial de la Salud promueve un compromiso con el envejecimiento saludable. La autopsia constituye el método más completo para el estudio de las enfermedades, y en los fallecidos de la tercera edad se evidencian sus problemas de salud. Objetivo: Mostrar las particularidades en edad, sexo, enfermedades crónicas, en particular los tumores malignos, la sepsis y causas de muerte que se encuentran en las autopsias de fallecidos de la tercera edad. Método: se realizó un estudio retrospectivo, longitudinal, entre los años 1987-2017 de las autopsias en fallecidos de la tercera edad. Se agrupan por edades: edad avanzada, anciana y grande longeva. Se exploran las variables de edad y sexo, enfermedades crónicas, infección y causas de muerte. Resultados: Los fallecidos de la tercera edad constituyen más de las tres cuartas partes de las autopsias en la institución. El sexo femenino muestra mayor longevidad. La hipertensión arterial, diabetes y el cáncer decrecen con la edad, mientras la sepsis se incrementa. Aumentan progresivamente en las causas de muerte directa, la sepsis y el tromboembolismo, mientras disminuyen el choque, edema pulmonar e infarto cardiaco. Aumenta en las causas básicas la aterosclerosis cerebral y generalizada, disminuye la coronaria, la enfermedad hipertensiva y los tumores malignos. La no coincidencia clínico patológica aumenta con la edad, discretamente. Conclusiones: Existen particularidades en el estudio de los pacientes de la tercera edad, evidenciado por los resultados de autopsia, por lo que se recomienda la geriatrización de los servicios(AU)

Introduction: The World Health Organization promotes a commitment to healthy aging. The autopsy is the most complete method for the study of the diseases and in the elderly deceased their health problems are evidenced. Objective: To show the particularities in ages, sex, chronic diseases, in particular malignant tumors, sepsis and causes of death found in the autopsies of the deceased elderly people. Method: A retrospective, longitudinal study was carried out between the years 1987-2017 of autopsies in elderly deceased. They were grouped by age: advanced age, elderly and long-lived. The variables age, sex, chronic diseases, infection and causes of death were explored. Results: The elderly deceased were more than three quarters of the autopsies in the institution. The female sex showed greater longevity. Hypertension, diabetes and cancer decreased with age, while sepsis increased. Sepsis and thromboembolism were progressively increasing in the direct causes of death, while shock, pulmonary edema and cardiac infarction decreased. In basic causes, cerebral and generalized atherosclerosis increased and coronary atherosclerosis, hypertensive disease and malignant tumors decreased. The clinical - pathology no coincidence, increased slightly with age. Conclusions: There are particularities in the studies of elderly patients evidenced by the results of autopsy, so that geriatrification of services is necessary(AU)

National and Subnational Trends in Mortality and Causes of Death in Chinese Children and Adolescents Aged 5-19 Years From 1953 to 2016.

PURPOSE: We aimed to analyze the recent trends of mortality and rankings of causes of death in Chinese children and adolescents from 1953 to 2016. METHODS: Data on mortality and causes of death in Chinese children and adolescents aged 5-19 years were extracted from the China Health Statistics Yearbook and the Global Burden of Disease Study from 1953 to 2016. Mortality variations were analyzed by year, age, sex, province, and causes of death. RESULTS: The mortality of Chinese children and adolescents aged 5-19 years declined steadily from 1953 (366.03/100,000) to 2016 (27.21), with the largest reduction in adolescents aged 15-19 years and the smallest reduction in those aged 10-14 years. Large subnational disparities for all-cause mortality existed in national 31 provinces with higher mortality in western regions compared with eastern regions, but with narrowing disparities between 1981 and 2010. Injuries dominated the causes of death compared with noncommunicable diseases and communicable, maternal and neonatal, and nutritional diseases from 1990 (58.13/100,000 vs. 32.10 and 14.31) to 2016 (22.65 vs. 13.00 and 2.93). In 2016, the leading three causes of death were road injuries (8.30/100,000), drowning (7.25), and leukemia (2.60). Drowning was the leading cause of death for 5- to 14-year-olds, but road injuries have been the leading cause for 15- to 19-year-olds of both sexes since 2010. CONCLUSIONS: Although mortality in Chinese adolescents now stands at just 7% of rates in the 1950s, there is a need to address continuing inequalities across sex, economic status, and region.

Analysis of the main causes of death and life loss of elderly people over 60 years old in a community in Shanghai, 2012-2019 / 公共卫生与预防医学

Objective To analyze the main causes of death among elderly residents aged 60 and above in Huangdu, Jiading District, Shanghai, and to provide evidence for disease prevention and control of the elderly. Methods The mortality rate, potential years of life lost (PYLL), years of life lost rate (PYLLR), and average years of life lost (AYLL) were calculated to evaluate the death characteristics and life loss of the elderly over 60 years old in Huangdu. Results From 2012 to 2019, there were 1 648 deaths among elderly people over 60 years old, and the death rate was 22.56‰. The mortality rate of residents was basically stable over time (P = 0.315). The top five causes of death were tumor, cerebrovascular disease, cardiovascular disease, respiratory diseases, and injury and poisoning, accounting for 81.67% of all deaths. The mortality of tumors and respiratory diseases was higher in males than in females, and the differences were statistically significant (both P0.05). Among the causes of death of residents aged 60 and above, the number of years of life lost caused by all causes of death was 5,512.5 (person-years), the rate of years of life lost was 88.69‰, and the average number of years of life lost was 8.14 (years/person). Conclusion Tumor and cardiovascular and cerebrovascular diseases were the main causes of death in the elderly in Huangdu area. Family doctors should be used to strengthen the prevention and control measures for cancer, cardiovascular and cerebrovascular diseases to improve the quality of life of the elderly in the area.

Cause-of-death analysis in low-risk cardiac surgery patients during postoperative period / 中国胸心血管外科临床杂志

@#Objective    To analyze the cause of death in low-risk cardiac surgery patients during postoperative period and discuss the prevention and treatment methods to increase the survival rate. Methods    We retrospectively analyzed the clinical data of 132 patients dead after cardiac surgery from January 2014 to December 2018, among whom 35 patients had a EuroSCORE Ⅱ score <4% (low-risk cardiac surgery patients), including 20 males and 15 females aged 62.7±13.4 years. The cause of death in these low-risk patients was analyzed. Results    The main causes of death were cardiogenic and brain-derived causes (60.0%), and infections and ogran failure (45.7%). Pulmonary infection and low cardiac output after surgery were the main causes of death. Cerebral infarction, malignant arrhythmia and multiple organ failure were the common causes of death. There were 4 deaths (11.4%) caused by accidents, including gastrointestinal bleeding caused by esophageal ultrasound probe, cough and asphyxia caused by drinking water, postoperative paralytic ileus and multiple perioperative allergic reactions caused by allergic constitution. Conclusion    Postoperative treatment and prevention for low-risk cardiac surgery patients should be focused on postoperative infection, and cardiac and brain function protection. Changes in various organ functions need to be closely monitored for preventing organ failure, accidents should be strictly controlled, and more details of intraoperative and postoperative treatment still need to be further improved.

Causas de Muerte Poco Útiles en el Hospital de Atención Integral del Adulto Mayor, Quito 2018 / Mortality Garbage Codes use in Hospital de Atención Integral del Adulto Mayor, 2018

INTRODUCCIÓN: En este trabajo, se analiza la situación y principales características de las causas de muerte "poco útiles" del Hospital de Atención Integral del Adulto Mayor (HAIAM). Se proceso la base de datos sobre defunción de enero a julio del 2018, que se encuentra validada según los criterios vigentes para identificación y análisis de la exactitud de la información sobre las causas básicas de muerte. METODOLOGÍA: Estudio descriptivo, cuantitativo, transversal. El universo son los registros de defunciones totales ocurridas de enero a julio del 2018. Se calcula el porcentaje de las causas de muerte "poco útiles" en el total de defunciones del HAIAM, incluye muertes de más y menos de 48 horas. RESULTADOS: 3 de cada 10 muertes registradas corresponde a causas "poco útiles" durante el período analizado, con un 24% de causas poco útiles. Dentro de estos el más alto porcentaje (50%) corresponde a causas sin suficiente especificación.  El 47% corresponde a causas intermedias de muerte, y un 3% como causas de defunción mal definidas. CONCLUSIÓN: La importancia de verificar la calidad de la información en relación a mortalidad aplicando los códigos garbage para validar las causas de muerte representa un aporte importante en relación a la calidad de información. Las causas de muerte mal definidas alteran el análisis de la información clínica y epidemiológica.(au)

BACKGROUND: this article analyzes the use and the main characteristics of mortality garbage codes in Hospital de Atención Integral del Adulto Mayor (HAIAM). The death database was processed from January to July 2018, which was validated according to the current criteria for the identification and analysis of the accuracy of the information on the basic causes of death. METHODS: Descriptive, quantitative, cross-sectional study. The universe is the total of deaths that occurred from January to July 2018. The percentage of mortality garbage codes in from total deaths of HAIAM was calculated, including deaths of more and less than 48 hours. RESULTS: 3 out of every 10 deaths registered correspond to "garbage codes" during the analyzed period, corresponding to 24% of garbage codes. The highest percentage (50%) were death causes with poor specification. 47% where intermediate causes of death and 3% poorly defined causes of death. CONCLUSION: The importance of verifying the quality of information about mortality, using garbage codes to validate death causes, is an important contribution. Garbage codes alter the appropriate analysis of clinical and epidemiological information.(au)

[Temporal trend of premature mortality for external causes in Chile between 1997-2014]. / Evolución temporal de la mortalidad prematura por causas externas en Chile entre 1997-2014.

OBJECTIVE: Currently, there is a change in the causes of mortality towards noncommunicable diseases and external causes. However, there are no updated studies on the trend of premature mortality due to external causes (PMEC) in Chile and the underlying sociodemographic variables. The objective of this study was to evaluate the trend of PMEC in Chile between 1997-2014 and analyze its distribution according to sociodemographic variables. METHODS: Ecological mixed study. The cause of death and demographic data of mortality databases and official population estimates of the government of Chile were used. The PMEC and main subcauses (traffic accidents, self-inflicted injuries and aggressions) were considered in the population between 15-64 years. Annual crudes and adjusted rates (direct method) were estimated between 1997-2014. The trend of adjusted rates was evaluated using Prais-Winsten regression. RESULTS: There were 102.559 deaths from external causes during the period studied (22.1% of total mortality). The cases were concentrated in men (85.3%), in the group of 25-44 years (44.8%) and at the basic instruction level-without instruction (48,4%). The PMEC trend decreased significantly in general population (ß=-1.18x100,000 inhab., 95%CI: -1.58,-0.78) and men (ß=-2.25x100,000 inhab. 95%CI: -2.79;-1.7). In women, there were no significant changes in PMEC, however an increase in PM due to aggressions was observed (ß=0.03x100,000 inhab. 95%CI: 0.002,0.05). CONCLUSIONS: During the study period, a decrease in MPCE could be observed, especially that caused by traffic accidents. However, it has not been possible to reduce in women, alerting the increase in MP due to aggressions.

OBJETIVO: Actualmente existe un desplazamiento de las causas de mortalidad hacia las enfermedades no transmisibles y causas externas. Sin embargo, no hay estudios actualizados sobre la tendencia de la mortalidad prematura por causas externas (MPCE) en Chile y sus variables sociodemográficas. El objetivo del estudio fue evaluar la tendencia de la MPCE en Chile entre 1997-2014 y analizar su distribución según variables sociodemográficas. METODOS: Estudio ecológico mixto. Se utilizó la causa de muerte y los datos demográficos de las bases de mortalidad y estimaciones de población oficiales del gobierno de Chile. Se consideró la MPCE y las causas específicas principales (accidentes de tránsito, lesiones autoinflingidas y agresiones) en la población entre 15-64 años. Se estimaron tasas anuales crudas y ajustadas (método directo) entre 1997-2014. Se evaluó la tendencia de las tasas ajustadas utilizando regresión de Prais-Winsten. RESULTADOS: Hubo 102.559 muertes por causas externas durante el período estudiado (22,1% de la mortalidad total). Los casos se concentraron en hombres (85,3%), en el grupo de 25-44 años (44,8%) y en el nivel de instrucción básico-sin instrucción (48,4%). La tendencia de la MPCE disminuyó significativamente en la población general (ß =-1,18x100.000 habs. IC95%:-1,58;-0,78) y en hombres (ß=-2,25x100.000 habs. IC95%:-2,79;-1,7). En mujeres no hubo cambios significativos en la MPCE, no obstante, se observó un aumento en la MP por agresiones (ß=0,03x100.000 habs. IC95%:0,002;0,05). CONCLUSIONES: Durante el período de estudio se pudo observar una disminución de la MPCE, especialmente la causada por accidentes de tránsito. Sin embargo, no se ha logrado reducir en mujeres, alertando el aumento en la MP por agresiones en este grupo.

Mortalidade de mulheres em idade reprodutiva: estudo comparativo entre dois períodos / Mortality in women of reproductive age: a comparative study between two periods / La mortalidad en las mujeres en edad reproductiva: un estudio comparativo entre los dos períodos

Objetivo: Identificar os fatores sociodemográficos associados com a mortalidade de mulheres em idade fértil do Paraná nos períodos de 1996 e 2014. Método: Trata-se de um estudo ecológico transversal descritivo com dados coletados por meio do Sistema de Informação de Mortalidade e processados pelo teste de associação qui-quadrado. Resultados: Houve uma redução na prevalência de óbitos das mulheres em idade fértil nos períodos, de 17% para 13,2%, respectivamente. As principais causas de morte para ambos os períodos ocorreram por causas evitáveis sendo as principais causas básicas as causas externas, neoplasias, doenças cardíacas e do aparelho circulatório. Conclusões: Os resultados contribuíram para mostrar que as mortes de MIF são evitáveis a partir da introdução de medidas sociais e de diagnóstico e tratamento precoce. O padrão de mortalidade do estado é semelhante ao do país apontando necessidade de implementar ações nas três esferas de governo voltadas para a saúde da população feminina

Objective: The purpose has been to identify socio-demographic factors associated with mortality in women of reproductive age in the Paraná State from 1996 to 2012. Methods: It is a descriptive and cross-sectional study with an ecological approach. Data were collected through the mortality information system and processed by the Chi-square test for association. Results: There was a reduction in the prevalence of deaths in women of reproductive age over the period considered, from 17% to 13.2%, respectively. The leading causes of death for both periods occurred from preventable causes being the main underlying causes external ones, such as cancer, heart disease and circulatory system. Conclusions: The results supported that deaths in women of reproductive age are preventable with the introduction of social actions, as well as early diagnosis and treatment. The mortality pattern in the Paraná State is similar to the country, which points to the need of implementing actions towards all three government levels focused on the female population health

Objetivo: Identificar los factores sociodemográficos asociados a la mortalidad de las mujeres en edad fértil de Paraná entre 1996 y 2012. Método: Estudio ecológico descriptivo transversal, con los datos recogidos a través del Sistema de Información sobre Mortalidad y procesados por la prueba asociación Chi-cuadrado. Resultados: Hubo reducción en la prevalencia de las muertes de mujeres en edad fértil en el período, del 17% al 13,2%, respectivamente. Las principales causas de muerte para ambos períodos se produjo por causas prevenibles siendo principal causa subyacente causas externas, cáncer, enfermedades del corazón y el sistema circulatorio. Conclusiones: Las muertes del MIF son prevenibles con la introducción de medidas de carácter social y el diagnóstico y tratamiento tempranos. El estado del patrón de mortalidad es similar a la de la nation que señalan la necesidad de implementar acciones en los tres niveles de gobierno se centraron en la salud de la población femenina

Mortalidade infantil evitável e vulnerabilidade social no vale do jequitinhonha, Minas Gerais, Brasil / Avoidable child mortality and social vulnerability in vale do jequitinhonha, Minas Gerais, Brazil / Mortalidad infantil evitable y vulnerabilidad social en el Valle del Jequitinhonha, Minas Gerais, Brasil

OBJETIVO: analisar a ocorrência de mortalidade infantil segundo critérios de evitabilidade e de vulnerabilidade social no Vale do Jequitinhonha, Minas Gerais. MÉTODOS: estudo transversal realizado com dados dos sistemas de informação do Ministério da Saúde, entre 2009 e 2014. Foi considerado o índice de vulnerabilidade social das cidades e as causas de morte foram classificadas conforme lista de causas evitáveis por intervenção do SUS. Foram calculadas as proporções, taxas corrigidas de mortalidade infantil geral e estratificadas. Diferenças foram avaliadas por meio do teste qui-quadrado em todo o período e entre os triênios 2009-11 e 2012-14. RESULTADOS: a taxa de mortalidade infantil média foi de 21,7 óbitos /1.000 nascidos vivos. No total, 69,5% dos óbitos foram classificados como evitáveis. Foram observadas reduções de 34,9 e 26,5% nos óbitos evitáveis por ações de atenção à mulher na gestação (p=0,00) e ao recém-nascido (p=0,04), respectivamente, e aumento de 65,8% nos óbitos evitáveis por ações de atenção à mulher no parto (p=0,01). Foi demonstrada predominância de óbitos evitáveis nos municípios de mais vulnerabilidade social (p=0,00). CONCLUSÕES: os resultados destacaram a importância das causas evitáveis relacionadas ao cuidado em saúde no momento do parto e, apesar das reduções observadas, na gestação e ao recém-nascido. Também evidenciaram a maior proporção de óbitos evitáveis na população mais vulnerável. O desafio de reduzir essa mortalidade indica a urgência por ações que visem à redução das desigualdades sociais, bem como a necessidade de melhorias no acesso e na qualidade dos serviços assistenciais.(AU)

Objective: to analyze the occurrence of child mortality according to avoidability and social vulnerability criteria in Vale do Jequitinhonha, Minas Gerais. Methods: a crosssectional study conducted with data from the Ministry of Health's information systems between 2009 and 2014. The social vulnerability index of the cities was considered and the causes of death were classified according to the list of preventable causes by SUS intervention. The proportions, and corrected rates of general and stratified child mortality were calculated. The differences were assessed using the Chi-square test, throughout the period and between the three year periods of 2009-11 and 2012- 14. Results: the mean infant mortality rate was 19.5 deaths/1,000 live births. In the total, 69.6% of the deaths were classified as preventable. Reductions were observed of 35.7% and 26.1% in the preventable deaths due to actions of care to women during pregnancy (p = 0.00) and newborns (p = 0.04), respectively, and an increase of 71.3% in preventable deaths due to actions of care to women in childbirth (p = 0.01). A predominance of preventable deaths was demonstrated in municipalities with greater social vulnerability (p = 0.00). Conclusions: the results highlighted the importance of preventable causes related to health care at delivery and, despite the observed reductions, in pregnancy and the newborn. They also evidenced the highest proportion ...(AU)

Objetivo: analizar la incidencia de mortalidad infantil según los criterios de prevención y vulnerabilidad social en el Valle del Jequitinhonha, Minas Gerais. Métodos: estudio transversal realizado con datos de los sistemas de información del Ministerio de Salud, entre 2009 y 2014. Se consideró el índice de vulnerabilidad social de las ciudades y las causas de muerte se clasificaron según la lista de causas evitables por intervención del SUS. Se calcularon las proporciones, las tasas corregidas de mortalidad infantil general y estratificadas. Las diferencias se evaluaron mediante la prueba de chi-cuadrado durante todo el período y entre los trienios 2009-11 y 2012-14. Resultados: la tasa promedio de mortalidad infantil era de 21,7 muertes / 1.000 nacimientos vivos. En total, el 69,5% de las muertes se clasificaron como evitables. Se observaron reducciones de 34,9 y 26,5% en muertes prevenibles debido a acciones de atención de las mujeres durante el embarazo (p = 0.00) y recién nacidos (p = 0,04), respectivamente, y un aumento de 65, 8% en muertes evitables mediante acciones de atención a mujeres en el parto (p = 0.01). La prevalencia de muertes evitables se demostró en municipios con mayor vulnerabilidad social (p = 0,00). Conclusiones: los resultados realzaron la importancia de las causas evitables relacionadas con la atención médica en el parto y, a pesar de las reducciones observadas, en el embarazo y el recién nacido. También mostraron la mayor proporción de muertes evitables en la población más vulnerable. El desafío de reducir esta mortalidad indica la urgencia de acciones dirigidas a reducir las desigualdades sociales, así como la necesidad de mejorar el acceso y la calidad de los servicios asistenciales.(AU)

Trajectories in hypnotic use and approaching death: a register linked case-control study.

PURPOSE: Whether the association between hypnotic and increased mortality risk is created by causation or confounding, has been long debated. We further examined the possibility of confounding by indication with a comprehensive approach. METHODS: The National FINRISK Study cohorts of 1997, 2002, and 2007 (25,436 participants aged 25-74) were followed up until July 2012. There were 1822 deaths, and at least one gender, baseline age and cohort matched 'control' was found for 1728 'cases' yielding a final analytical sample of 3955 individuals. An index age, equivalent to the age at death of their respective cases' was set for each control. Hypnotic drug purchases were followed from the Finnish nationwide register during a 36-month run-up period before the date of death/index date. The prevalence and incidence of hypnotic purchases were compared between cases and matched controls. Moreover, latent developmental trajectories of purchases were modelled and their relations with specific and all-cause death risks were analysed. RESULTS: An increasing difference between cases and controls was observed as regards the use of hypnotic drugs. During the last 30 months before the date of death/index date, the rate ratio of incident purchases between cases and controls was 2.37 (95% CL, 1.79-3.12) among older and 3.61 (95% CL, 2.37-5.89) among younger individuals. The developmental trajectories of hypnotic drug purchases were differently and by interpretation plausibly associated with specific mortality risks. CONCLUSIONS: In most cases the association between hypnotics and mortality risk is created by symptomatic treatment when death is approaching.